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Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide
Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake. Here, we demonstrate that a fatty acylated peptide exhibits...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529511/ https://www.ncbi.nlm.nih.gov/pubmed/34712919 http://dx.doi.org/10.1016/j.isci.2021.103220 |