Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools

Targeted bacteriophage (phage) particles are potentially attractive yet inexpensive platforms for immunization. Herein, we describe targeted phage capsid display of an immunogenically relevant epitope of the SARS-CoV-2 Spike protein that is empirically conserved, likely due to the high mutational co...

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Autores principales: Markosian, Christopher, Staquicini, Daniela I., Dogra, Prashant, Dodero-Rojas, Esteban, Tang, Fenny H. F., Smith, Tracey L., Contessoto, Vinícius G., Libutti, Steven K., Wang, Zhihui, Cristini, Vittorio, Whitford, Paul C., Burley, Stephen K., Onuchic, José N., Pasqualini, Renata, Arap, Wadih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529634/
https://www.ncbi.nlm.nih.gov/pubmed/34676381
http://dx.doi.org/10.1101/2021.08.30.458222
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author Markosian, Christopher
Staquicini, Daniela I.
Dogra, Prashant
Dodero-Rojas, Esteban
Tang, Fenny H. F.
Smith, Tracey L.
Contessoto, Vinícius G.
Libutti, Steven K.
Wang, Zhihui
Cristini, Vittorio
Whitford, Paul C.
Burley, Stephen K.
Onuchic, José N.
Pasqualini, Renata
Arap, Wadih
author_facet Markosian, Christopher
Staquicini, Daniela I.
Dogra, Prashant
Dodero-Rojas, Esteban
Tang, Fenny H. F.
Smith, Tracey L.
Contessoto, Vinícius G.
Libutti, Steven K.
Wang, Zhihui
Cristini, Vittorio
Whitford, Paul C.
Burley, Stephen K.
Onuchic, José N.
Pasqualini, Renata
Arap, Wadih
author_sort Markosian, Christopher
collection PubMed
description Targeted bacteriophage (phage) particles are potentially attractive yet inexpensive platforms for immunization. Herein, we describe targeted phage capsid display of an immunogenically relevant epitope of the SARS-CoV-2 Spike protein that is empirically conserved, likely due to the high mutational cost among all variants identified to date. This observation may herald an approach to developing vaccine candidates for broad-spectrum, towards universal, protection against multiple emergent variants of coronavirus that cause COVID-19.
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spelling pubmed-85296342021-10-21 Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools Markosian, Christopher Staquicini, Daniela I. Dogra, Prashant Dodero-Rojas, Esteban Tang, Fenny H. F. Smith, Tracey L. Contessoto, Vinícius G. Libutti, Steven K. Wang, Zhihui Cristini, Vittorio Whitford, Paul C. Burley, Stephen K. Onuchic, José N. Pasqualini, Renata Arap, Wadih bioRxiv Article Targeted bacteriophage (phage) particles are potentially attractive yet inexpensive platforms for immunization. Herein, we describe targeted phage capsid display of an immunogenically relevant epitope of the SARS-CoV-2 Spike protein that is empirically conserved, likely due to the high mutational cost among all variants identified to date. This observation may herald an approach to developing vaccine candidates for broad-spectrum, towards universal, protection against multiple emergent variants of coronavirus that cause COVID-19. Cold Spring Harbor Laboratory 2021-08-30 /pmc/articles/PMC8529634/ /pubmed/34676381 http://dx.doi.org/10.1101/2021.08.30.458222 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Markosian, Christopher
Staquicini, Daniela I.
Dogra, Prashant
Dodero-Rojas, Esteban
Tang, Fenny H. F.
Smith, Tracey L.
Contessoto, Vinícius G.
Libutti, Steven K.
Wang, Zhihui
Cristini, Vittorio
Whitford, Paul C.
Burley, Stephen K.
Onuchic, José N.
Pasqualini, Renata
Arap, Wadih
Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title_full Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title_fullStr Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title_full_unstemmed Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title_short Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
title_sort apropos of universal epitope discovery for covid-19 vaccines: a framework for targeted phage display-based delivery and integration of new evaluation tools
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529634/
https://www.ncbi.nlm.nih.gov/pubmed/34676381
http://dx.doi.org/10.1101/2021.08.30.458222
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