Cargando…
Enhanced IL-2 in early life limits the development of T(FH) and protective antiviral immunity
T follicular helper cell (T(FH))–dependent antibody responses are critical for long-term immunity. Antibody responses are diminished in early life, limiting long-term protective immunity and allowing prolonged or recurrent infection, which may be important for viral lung infections that are highly p...
Autores principales: | Pyle, Chloe J., Labeur-Iurman, Lucia, Groves, Helen T., Puttur, Franz, Lloyd, Clare M., Tregoning, John S., Harker, James A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529914/ https://www.ncbi.nlm.nih.gov/pubmed/34665220 http://dx.doi.org/10.1084/jem.20201555 |
Ejemplares similares
-
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology
por: Pyle, Chloe J., et al.
Publicado: (2017) -
Mechanisms of FH Protection Against Neovascular AMD
por: Borras, Céline, et al.
Publicado: (2020) -
Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection
por: Peiró, Teresa, et al.
Publicado: (2018) -
Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding
por: Costa, Isabella, et al.
Publicado: (2014) -
IL-7 signalling represses Bcl-6 and the T(FH) gene program
por: McDonald, Paul W., et al.
Publicado: (2016)