Cargando…

Substantial acetylcholine reduction in multiple brain regions of Mecp2-deficient female rats and associated behavioral abnormalities

Rett syndrome (RTT) is a neurodevelopmental disorder with X-linked dominant inheritance caused mainly by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. The effects of various Mecp2 mutations have been extensively assessed in mouse models, but none adequately mimic the symptoms and patho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murasawa, Hiroyasu, Kobayashi, Hiroyuki, Imai, Jun, Nagase, Takahiko, Soumiya, Hitomi, Fukumitsu, Hidefumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530288/ https://www.ncbi.nlm.nih.gov/pubmed/34673817 http://dx.doi.org/10.1371/journal.pone.0258830

Ejemplares similares

Ethanol Extract of Chinese Propolis Facilitates Functional Recovery of Locomotor Activity after Spinal Cord Injury
por: Kasai, Masaki, et al.
Publicado: (2011)

Injury-Induced Accumulation of Glial Cell Line-Derived Neurotrophic Factor in the Rostral Part of the Injured Rat Spinal Cord
por: Hara, Takuya, et al.
Publicado: (2012)

2-Decenoic Acid Ethyl Ester, a Compound That Elicits Neurotrophin-like Intracellular Signals, Facilitating Functional Recovery from Cerebral Infarction in Mice
por: Tanaka, Yoshitaka, et al.
Publicado: (2012)

A novel 2-decenoic acid thioester ameliorates corticosterone-induced depression- and anxiety-like behaviors and normalizes reduced hippocampal signal transduction in treated mice
por: Shibata, Shoyo, et al.
Publicado: (2015)

Neonatal Whisker Trimming Impairs Fear/Anxiety-Related Emotional Systems of the Amygdala and Social Behaviors in Adult Mice
por: Soumiya, Hitomi, et al.
Publicado: (2016)

Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model
por: Ito, Satoru, et al.
Publicado: (2012)

Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation
por: Lang, Min, et al.
Publicado: (2014)

Daily Rhythmic Behaviors and Thermoregulatory Patterns Are Disrupted in Adult Female MeCP2-Deficient Mice
por: Wither, Robert G., et al.
Publicado: (2012)

MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats
por: Patterson, Kelsey C., et al.
Publicado: (2016)

MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats
por: Patterson, Kelsey C., et al.
Publicado: (2016)

Rett syndrome (MECP2) and succinic semialdehyde dehydrogenase (ALDH5A1) deficiency in a developmentally delayed female
por: Brown, Madalyn, et al.
Publicado: (2019)

MECP2 duplication phenotype in symptomatic females: report of three further cases
por: Novara, Francesca, et al.
Publicado: (2014)

De novo mosaic MECP2 mutation in a female with Rett syndrome
por: Alexandrou, Angelos, et al.
Publicado: (2019)

MeCP2 Dependent Heterochromatin Reorganization during Neural Differentiation of a Novel Mecp2-Deficient Embryonic Stem Cell Reporter Line
por: Bertulat, Bianca, et al.
Publicado: (2012)

Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain
por: Panayotis, Nicolas, et al.
Publicado: (2011)

Intrinsic hippocampal network activity is altered in MeCP2-deficient mice
por: Zhang, Liang, et al.
Publicado: (2007)

MeCP2 Deficiency Leads to Loss of Glial Kir4.1
por: Kahanovitch, Uri, et al.
Publicado: (2018)

MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome
por: Jin, Xu-Rui, et al.
Publicado: (2017)

Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome
por: Kahanovitch, Uri, et al.
Publicado: (2019)

Protective role of mirtazapine in adult female Mecp2(+/−) mice and patients with Rett syndrome
por: Flores Gutiérrez, Javier, et al.
Publicado: (2020)

Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
por: Collins, Bridget E, et al.
Publicado: (2022)

Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin
por: Villani, Claudia, et al.
Publicado: (2021)

GABA and Glutamate Pathways Are Spatially and Developmentally Affected in the Brain of Mecp2-Deficient Mice
por: El-Khoury, Rita, et al.
Publicado: (2014)

Identification of Region-Specific Cytoskeletal and Molecular Alterations in Astrocytes of Mecp2 Deficient Animals
por: Albizzati, Elena, et al.
Publicado: (2022)

Highly Efficient Perovskite Solar Cells with Substantial Reduction of Lead Content
por: Liu, Chong, et al.
Publicado: (2016)

Determinants of substantial public debt reductions in Central and Eastern European Countries
por: Semik, Sofia, et al.
Publicado: (2021)

MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
por: Krishnan, Keerthi, et al.
Publicado: (2017)

MECP2 Duplications in Symptomatic Females: Report on 3 Patients Showing the Broad Phenotypic Spectrum
por: San Antonio-Arce, Victoria, et al.
Publicado: (2016)

Persistent Unresolved Inflammation in the Mecp2-308 Female Mutated Mouse Model of Rett Syndrome
por: Cortelazzo, Alessio, et al.
Publicado: (2017)

Detection of neurophysiological features in female R255X MeCP2 mutation mice
por: Dong, Hong-Wei, et al.
Publicado: (2020)

Priming with FGF2 stimulates human dental pulp cells to promote axonal regeneration and locomotor function recovery after spinal cord injury
por: Nagashima, Kosuke, et al.
Publicado: (2017)

Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome
por: Ehinger, Yann, et al.
Publicado: (2021)

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge
por: Zalosnik, M. I., et al.
Publicado: (2021)

MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning
por: Yue, Yuanlei, et al.
Publicado: (2022)

Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine
por: Zou, Xuan, et al.
Publicado: (2020)

Antibiotic‐induced reduction of abnormal lung shadow in pulmonary nodular lymphoid hyperplasia
por: Tanino, Akari, et al.
Publicado: (2020)

Medical Comorbidities in MECP2 Duplication Syndrome: Results from the International MECP2 Duplication Database
por: Ta, Daniel, et al.
Publicado: (2022)

Duplication within two regions distal to MECP2: clinical similarity with MECP2 duplication syndrome
por: Akahoshi, Keiko, et al.
Publicado: (2023)

Analyzing Nursing Home Complaints: From Substantiated Allegation to Deficiency Citations
por: Bhattacharyya, Kallol Kumar, et al.
Publicado: (2020)

MeCP2 and Chromatin Compartmentalization
por: Schmidt, Annika, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o76n8edhil0tgs31lb8r5glgka