β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca(2+)-permeable AMPA receptors

Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) synaptic plasticity underlying learning and memory. In Alzheimer’s disease β-amyloid (Aβ) oligomers may impair learning and memory by alt...

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Detalles Bibliográficos
Autores principales: Sanderson, Jennifer L., Freund, Ronald K., Gorski, Jessica A., Dell’Acqua, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530450/
https://www.ncbi.nlm.nih.gov/pubmed/34610314
http://dx.doi.org/10.1016/j.celrep.2021.109786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530450/
https://www.ncbi.nlm.nih.gov/pubmed/34610314
http://dx.doi.org/10.1016/j.celrep.2021.109786

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