Brain proteome-wide association study implicates novel proteins in depression pathogenesis

Depression is a common condition but current treatments for depression are only effective in a subset of individuals. To identify novel treatment targets, we integrated depression GWAS results (N=500,199) with human brain proteomes (N=376) to perform a proteome-wide association study (PWAS) of depre...

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Detalles Bibliográficos
Autores principales: Wingo, Thomas S., Liu, Yue, Gerasimov, Ekaterina S., Gockley, Jake, Logsdon, Benjamin A., Duong, Duc M., Dammer, Eric B., Lori, Adriana, Kim, Paul J., Ressler, Kerry J., Beach, Thomas G., Reiman, Eric M., Epstein, Michael P., De Jager, Philip L., Lah, James J., Bennett, David A., Seyfried, Nicholas T., Levey, Allan I., Wingo, Aliza P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530461/
https://www.ncbi.nlm.nih.gov/pubmed/33846625
http://dx.doi.org/10.1038/s41593-021-00832-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530461/
https://www.ncbi.nlm.nih.gov/pubmed/33846625
http://dx.doi.org/10.1038/s41593-021-00832-6

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