HIF1α stabilization in hypoxia is not oxidant-initiated

Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second messenger peroxide. Here, we use a ratiometric, pero...

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Detalles Bibliográficos
Autores principales: Kumar, Amit, Vaish, Manisha, Karuppagounder, Saravanan S, Gazaryan, Irina, Cave, John W, Starkov, Anatoly A, Anderson, Elizabeth T, Zhang, Sheng, Pinto, John T, Rountree, Austin M, Wang, Wang, Sweet, Ian R, Ratan, Rajiv R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530508/
https://www.ncbi.nlm.nih.gov/pubmed/34596045
http://dx.doi.org/10.7554/eLife.72873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530508/
https://www.ncbi.nlm.nih.gov/pubmed/34596045
http://dx.doi.org/10.7554/eLife.72873

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