Cargando…

HIF1α stabilization in hypoxia is not oxidant-initiated

Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second messenger peroxide. Here, we use a ratiometric, pero...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Amit, Vaish, Manisha, Karuppagounder, Saravanan S, Gazaryan, Irina, Cave, John W, Starkov, Anatoly A, Anderson, Elizabeth T, Zhang, Sheng, Pinto, John T, Rountree, Austin M, Wang, Wang, Sweet, Ian R, Ratan, Rajiv R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530508/ https://www.ncbi.nlm.nih.gov/pubmed/34596045 http://dx.doi.org/10.7554/eLife.72873

Ejemplares similares

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease
por: Smirnova, Natalya A., et al.
Publicado: (2016)

A STING agonist preconditions against ischaemic stroke via an adaptive antiviral Type 1 interferon response
por: Kundu, Nandini, et al.
Publicado: (2022)

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
por: Sleiman, Sama F, et al.
Publicado: (2016)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
por: Savyuk, Maria, et al.
Publicado: (2020)

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors
por: Zille, Marietta, et al.
Publicado: (2019)

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis
por: Neitemeier, S, et al.
Publicado: (2016)

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration
por: Sleiman, Sama F., et al.
Publicado: (2011)

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery
por: Wei, George Z., et al.
Publicado: (2021)

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease
por: Mitroshina, Elena V., et al.
Publicado: (2021)

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson’s disease
por: Aimé, Pascaline, et al.
Publicado: (2020)

The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes
por: Guo, Hai, et al.
Publicado: (2017)

The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia
por: Zhang, Jianghong, et al.
Publicado: (2021)

Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α
por: Wang, Meng, et al.
Publicado: (2021)

HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy
por: Tang, Zonghao, et al.
Publicado: (2021)

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
por: Li, Jian, et al.
Publicado: (2022)

HIF repressors under chronic hypoxia
por: Luo, Weibo, et al.
Publicado: (2016)

BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment
por: Rountree, Austin, et al.
Publicado: (2016)

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia
por: Yang, Xing-Liang, et al.
Publicado: (2019)

HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression
por: Zhuang, Yu, et al.
Publicado: (2022)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

A new role for Hif-1α
por: Shin, Mingyu, et al.
Publicado: (2022)

Cycling hypoxia selects for constitutive HIF stabilization
por: Pressley, Mariyah, et al.
Publicado: (2021)

Mitochondrial calcium buffering depends upon temperature and is associated with hypothermic neuroprotection against hypoxia-ischemia injury
por: Sosunov, Sergey, et al.
Publicado: (2022)

Hypoxia/HIF Modulates Immune Responses
por: Chen, Yuling, et al.
Publicado: (2021)

Regulation of chromatin accessibility by hypoxia and HIF
por: Batie, Michael, et al.
Publicado: (2022)

HIF-stabilizing biomaterials: from hypoxia-mimicking to hypoxia-inducing
por: Colombani, Thibault, et al.
Publicado: (2023)

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia
por: Fuller, Gregory G, et al.
Publicado: (2020)

HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition
por: Geng, Hao, et al.
Publicado: (2021)

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
por: Brereton, Christopher J, et al.
Publicado: (2022)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
por: Poloznikov, Andrey A., et al.
Publicado: (2021)

Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum
por: Kuok, Iok Teng, et al.
Publicado: (2019)

N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
por: Karuppagounder, Saravanan S., et al.
Publicado: (2018)

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia
por: Bagnall, James, et al.
Publicado: (2014)

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
por: Mole, David R., et al.
Publicado: (2009)

Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis
por: Muz, Barbara, et al.
Publicado: (2009)

Hypoxia regulates RNA splicing of HIF targets
por: Hu, Cheng-Jun
Publicado: (2014)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts
por: Ding, Ding, et al.
Publicado: (2022)

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
por: Cimmino, Flora, et al.
Publicado: (2019)

Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly
por: Kumar, Amit, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lvt4ohnbtdmg6g48fedtsf221v