Cargando…
A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer
Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironments. In this study, we investigated the interconnected pathwa...
Autores principales: | Bertolini, Giulia, Cancila, Valeria, Milione, Massimo, Lo Russo, Giuseppe, Fortunato, Orazio, Zaffaroni, Nadia, Tortoreto, Monica, Centonze, Giovanni, Chiodoni, Claudia, Facchinetti, Federica, Pollaci, Giuliana, Taiè, Giulia, Giovinazzo, Francesca, Moro, Massimo, Camisaschi, Chiara, De Toma, Alessandro, D’Alterio, Crescenzo, Pastorino, Ugo, Tripodo, Claudio, Scala, Stefania, Sozzi, Gabriella, Roz, Luca |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530918/ https://www.ncbi.nlm.nih.gov/pubmed/34023505 http://dx.doi.org/10.1016/j.ymthe.2021.05.014 |
Ejemplares similares
-
Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
por: Fortunato, Orazio, et al.
Publicado: (2019) -
Patient-Derived Xenografts of Non Small Cell Lung Cancer: Resurgence of an Old Model for Investigation of Modern Concepts of Tailored Therapy and Cancer Stem Cells
por: Moro, Massimo, et al.
Publicado: (2012) -
Conversion to stem‐cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells
por: Andriani, Francesca, et al.
Publicado: (2015) -
Combination Treatment with All-Trans Retinoic Acid Prevents Cisplatin-Induced Enrichment of CD133(+) Tumor-Initiating Cells and Reveals Heterogeneity of Cancer Stem Cell Compartment in Lung Cancer
por: Moro, Massimo, et al.
Publicado: (2015) -
CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells
por: Fortunato, Orazio, et al.
Publicado: (2020)