TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs

Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly in human tumors. It plays a role in malignant transformation, apoptosis prevention, and DNA damage repair. The signaling mechanisms underlying TCTP regulation in cancer are only partially understood. Here, we...

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Detalles Bibliográficos
Autores principales: Jeong, Mini, Jeong, Mi Hyeon, Kim, Jung Eun, Cho, Serin, Lee, Kyoung Jin, Park, Serkin, Sohn, Jeongwon, Park, Yun Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531033/
https://www.ncbi.nlm.nih.gov/pubmed/34675258
http://dx.doi.org/10.1038/s41598-021-00247-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531033/
https://www.ncbi.nlm.nih.gov/pubmed/34675258
http://dx.doi.org/10.1038/s41598-021-00247-0

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