Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target’s expression or function, as a tool to anticipate the effect of drug action on the same target. Here we apply MR to prioritize drug targets for their causal rele...

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Detalles Bibliográficos
Autores principales: Gordillo-Marañón, María, Zwierzyna, Magdalena, Charoen, Pimphen, Drenos, Fotios, Chopade, Sandesh, Shah, Tina, Engmann, Jorgen, Chaturvedi, Nishi, Papacosta, Olia, Wannamethee, Goya, Wong, Andrew, Sofat, Reecha, Kivimaki, Mika, Price, Jackie F., Hughes, Alun D., Gaunt, Tom R., Lawlor, Deborah A., Gaulton, Anna, Hingorani, Aroon D., Schmidt, Amand F., Finan, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531035/
https://www.ncbi.nlm.nih.gov/pubmed/34675202
http://dx.doi.org/10.1038/s41467-021-25731-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531035/
https://www.ncbi.nlm.nih.gov/pubmed/34675202
http://dx.doi.org/10.1038/s41467-021-25731-z

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