Berberine and Its Main Metabolite Berberrubine Inhibit Platelet Activation Through Suppressing the Class I PI3Kβ/Rasa3/Rap1 Pathway

Background: Berberine (BBR), a natural product, was reported to inhibit platelet aggregation; however, the molecular mechanisms remain unclear. This study aims to investigate the effects and mechanisms of BBR in inhibiting platelet activation and thrombus formation. Methods: Flow cytometry, immunofl...

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Detalles Bibliográficos
Autores principales: Wang, Can, Cheng, Yangyang, Zhang, Yuanhui, Jin, Hongtao, Zuo, Zengyan, Wang, Aiping, Huang, Jianmei, Jiang, Jiandong, Kong, Weijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531212/
https://www.ncbi.nlm.nih.gov/pubmed/34690771
http://dx.doi.org/10.3389/fphar.2021.734603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531212/
https://www.ncbi.nlm.nih.gov/pubmed/34690771
http://dx.doi.org/10.3389/fphar.2021.734603

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