Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance

In obesity, macrophages drive a low-grade systemic inflammation (LSI) and insulin resistance (IR). The ribosome biosynthesis protein NOC4 (NOC4) mediates 40 S ribosomal subunits synthesis in yeast. Hereby, we reported an unexpected location and function of NOC4L, which was preferentially expressed i...

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Detalles Bibliográficos
Autores principales: Qin, Yongli, Jia, Lina, Liu, Huijiao, Ma, Wenqiang, Ren, Xinmin, Li, Haifeng, Liu, Yuanwu, Li, Haiwen, Ma, Shuoqian, Liu, Mei, Li, Pingping, Yan, Jinghua, Zhang, Jiyan, Guo, Yangdong, You, Hua, Guo, Yan, Rahman, Nafis A., Wołczyński, Sławomir, Kretowski, Adam, Li, Dangsheng, Li, Xiru, Ren, Fazheng, Li, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531303/
https://www.ncbi.nlm.nih.gov/pubmed/34675215
http://dx.doi.org/10.1038/s41467-021-26408-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531303/
https://www.ncbi.nlm.nih.gov/pubmed/34675215
http://dx.doi.org/10.1038/s41467-021-26408-3

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