Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor

In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against α-glucosidase activity. Newly identified inhibitors were found to be four to eighteen folds more active with IC(50) values in...

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Detalles Bibliográficos
Autores principales: Azimi, Fateme, Azizian, Homa, Najafi, Mohammad, Khodarahmi, Ghadamali, Saghaei, Lotfollah, Hassanzadeh, Motahareh, Ghasemi, Jahan B., Faramarzi, Mohammad Ali, Larijani, Bagher, Hassanzadeh, Farshid, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531348/
https://www.ncbi.nlm.nih.gov/pubmed/34675367
http://dx.doi.org/10.1038/s41598-021-99899-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531348/
https://www.ncbi.nlm.nih.gov/pubmed/34675367
http://dx.doi.org/10.1038/s41598-021-99899-1

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