Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death

Inhibitory PAS domain protein (IPAS) is a bifunctional protein that acts as a transcriptional repressor in hypoxia and as a pro-apoptotic protein involved in neuronal cell death. Npas4 (NXF or LE-PAS) is a transcriptional factor that protects nerve cells from endogenous and foreign neurotoxins. Here...

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Detalles Bibliográficos
Autores principales: Kasai, Shuya, Li, Xianyu, Torii, Satoru, Yasumoto, Ken-ichi, Sogawa, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531447/
https://www.ncbi.nlm.nih.gov/pubmed/34675183
http://dx.doi.org/10.1038/s41420-021-00690-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531447/
https://www.ncbi.nlm.nih.gov/pubmed/34675183
http://dx.doi.org/10.1038/s41420-021-00690-y

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