Cargando…
Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling
Under oxidative and electrophilic stresses, cells launch an NRF2-mediated transcriptional antioxidant program. The activation of NRF2 depends on a redox sensor, KEAP1, which promotes the ubiquitination and degradation of NRF2. While a great deal has been learned about this duo, its quantitative sign...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531862/ https://www.ncbi.nlm.nih.gov/pubmed/34600335 http://dx.doi.org/10.1016/j.redox.2021.102139 |