Cargando…

FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway

Osteoarthritis (OA) is a common degenerative disease that can lead to severe joint pain and loss of function, seriously threatening the health and normal life of patients. At present, the pathogenesis of OA remains to be clarified. Recent studies have shown that fatty acid-binding protein 4 (FABP4)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mao, Huajie, Han, Bin, Li, Hao, Tao, Yiqing, Wu, Weigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532115/ https://www.ncbi.nlm.nih.gov/pubmed/34651666 http://dx.doi.org/10.3892/mmr.2021.12495

Ejemplares similares

Fxyd5 activates the NF-κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation
por: Song, Lulu, et al.
Publicado: (2022)

CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling
por: Wei, Wei, et al.
Publicado: (2023)

Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis
por: Lin, Jiazhong, et al.
Publicado: (2023)

Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes
por: Dai, Linghui, et al.
Publicado: (2012)

α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice
por: Zhang, Huawei, et al.
Publicado: (2021)

CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation
por: He, Axiang, et al.
Publicado: (2023)

Knockdown of TRIM8 Attenuates IL-1β-induced Inflammatory Response in Osteoarthritis Chondrocytes Through the Inactivation of NF-κB Pathway
por: Liu, Ruoxi, et al.
Publicado: (2020)

Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes
por: Nebbaki, Salwa Sarah, et al.
Publicado: (2012)

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis: Nrf2/HMGB1 affects osteoarthritis
por: Li, Wenzhao, et al.
Publicado: (2023)

Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways
por: Lee, Hyesook, et al.
Publicado: (2016)

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β
por: Sun, Panpan, et al.
Publicado: (2022)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis
por: Xue, Xiang, et al.
Publicado: (2023)

Synovial tissue‐derived extracellular vesicles induce chondrocyte inflammation and degradation via NF‐κB signalling pathway: An in vitro study
por: Chen, Pu, et al.
Publicado: (2022)

Long noncoding RNA PVT1 promotes chondrocyte extracellular matrix degradation by acting as a sponge for miR-140 in IL-1β-stimulated chondrocytes
por: Yao, Nan, et al.
Publicado: (2022)

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
por: Rozema, E., et al.
Publicado: (2012)

Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy
por: Zhang, Yan, et al.
Publicado: (2014)

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
por: Dammann, Kyle, et al.
Publicado: (2015)

Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway
por: Deng, Yongbing, et al.
Publicado: (2019)

STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
por: Guo, Qiang, et al.
Publicado: (2021)

CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5
por: Wang, Haoran, et al.
Publicado: (2023)

Berberine prevents human nucleus pulposus cells from IL-1β-induced extracellular matrix degradation and apoptosis by inhibiting the NF-κB pathway
por: Lu, Lin, et al.
Publicado: (2019)

Comparative evaluation of the effects of platelet-rich plasma formulations on extracellular matrix formation and the NF-κB signaling pathway in human articular chondrocytes
por: Yin, Wenjing, et al.
Publicado: (2017)

Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways
por: Xu, Fang, et al.
Publicado: (2022)

A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes
por: Lamas Bervejillo, M., et al.
Publicado: (2019)

Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway
por: Chen, Nan-Nan, et al.
Publicado: (2023)

PPAR γ/Nnat/NF-κB Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation
por: Yang, Wenkai, et al.
Publicado: (2019)

Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression
por: Liu, Qiang, et al.
Publicado: (2016)

miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis
por: Bai, Yinwei, et al.
Publicado: (2020)

Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes
por: Yang, Bo, et al.
Publicado: (2021)

FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression
por: Miao, Lei, et al.
Publicado: (2021)

Extracellular matrix formation by chondrocytes in monolayer culture
Publicado: (1981)

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes
por: Wang, Mengying, et al.
Publicado: (2020)

Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
por: Hua, Tuyen N.M., et al.
Publicado: (2019)

Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice
por: Tang, Wanze, et al.
Publicado: (2023)

DHA Inhibits Protein Degradation More Efficiently than EPA by Regulating the PPARγ/NFκB Pathway in C2C12 Myotubes
por: Wang, Yue, et al.
Publicado: (2013)

Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
por: Mao, Jing-Wei, et al.
Publicado: (2012)

Trans‐repression of NFκB pathway mediated by PPARγ improves vascular endothelium insulin resistance
por: Kong, Ying, et al.
Publicado: (2018)

Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR-γ/NF-κB signaling pathway
por: Feng, Pingping, et al.
Publicado: (2020)

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes
por: Liang, Yujie, et al.
Publicado: (2016)

Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis
por: Wang, Xipeng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8d3jv80irgt2iofj1mrht11b9s