An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function

The αIIbβ3 integrin receptor coordinates platelet adhesion, activation, and mechanosensing in thrombosis and hemostasis. Using differential cysteine alkylation and mass spectrometry, we have identified a disulfide bond in the αIIb subunit linking cysteines 490 and 545 that is missing in ∼1 in 3 inte...

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Detalles Bibliográficos
Autores principales: Pijning, Aster E., Blyth, Mitchell T., Coote, Michelle L., Passam, Freda, Chiu, Joyce, Hogg, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532129/
https://www.ncbi.nlm.nih.gov/pubmed/34375384
http://dx.doi.org/10.1182/blood.2021012441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532129/
https://www.ncbi.nlm.nih.gov/pubmed/34375384
http://dx.doi.org/10.1182/blood.2021012441

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