Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle

The myosin motors in resting skeletal muscle are folded back against their tails in the thick filament in a conformation that makes them unavailable for binding to actin. When muscles are activated, calcium binding to troponin leads to a rapid change in the structure of the actin-containing thin fil...

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Detalles Bibliográficos
Autores principales: Reconditi, Massimo, Brunello, Elisabetta, Fusi, Luca, Linari, Marco, Lombardi, Vincenzo, Irving, Malcolm, Piazzesi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532561/
https://www.ncbi.nlm.nih.gov/pubmed/34668926
http://dx.doi.org/10.1085/jgp.202112896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532561/
https://www.ncbi.nlm.nih.gov/pubmed/34668926
http://dx.doi.org/10.1085/jgp.202112896

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