BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage

BACE1 is a key enzyme facilitating the generation of neurotoxic β-amyloid (Aβ) peptide. However, given that BACE1 has multiple substrates we explored the importance of BACE1 in the maintenance of retinal pigment epithelial (RPE) cell homeostasis under oxidative stress. Inhibition of BACE1 reduced mi...

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Detalles Bibliográficos
Autores principales: Francelin, Carolina, Mitter, Sayak K., Qian, Qingwen, Barodia, Sandeep Kumar, Ip, Colin, Qi, Xiaoping, Gu, Hongmei, Quigley, Judith, Goldberg, Matthew S., Grant, Maria B., Boulton, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532805/
https://www.ncbi.nlm.nih.gov/pubmed/34679674
http://dx.doi.org/10.3390/antiox10101539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532805/
https://www.ncbi.nlm.nih.gov/pubmed/34679674
http://dx.doi.org/10.3390/antiox10101539

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