Identification of Breed Differences in Known and New Fescue Toxicosis Associated Phenotypes in Charolais-and Hereford-Sired Crossbred Beef Cows

SIMPLE SUMMARY: The consumption of toxic fescue has caused significant losses in the U.S. beef industry. Widely accepted symptoms of toxic fescue exposure include the retention of a thick hair coat, tissue necrosis in the extremities, and reduced nutrient absorption. However, there is variability in the severity of these symptoms, both across and within breeds. The objective of this study was to characterize the effect of fescue toxicosis across Hereford- and Charolais-sired cows for known and new fescue stress-associated phenotypes. Results indicated that Hereford cows had a lessened ability to shed their winter coat and regulate body temperature along with lower serum mineral concentrations compared to Charolais cows when exposed to toxic fescue. Differences between and within sire breed in hair shedding were also observed, providing further evidence of genetic variation. This study provides evidence of variability in the fescue toxicosis that is potentially useful for genetic selection to reduce fescue stress and characterizes effects on pregnant cows which may impact calves in utero. ABSTRACT: Beef cattle phenotypes are affected by the consumption of toxic fescue. Toxic fescue’s impact is dependent on heat stress and breed composition, with genetic variability for robustness to toxin exposure believed to exist within and across breeds. The study objective was to characterize the effect of fescue toxicosis across breeds for known and novel heat and fescue stress-associated phenotypes. One-hundred crossbred fall-calving Charolais- and Hereford-sired cows of parities 1–3 were allocated to graze either toxic fescue (n = 50), non-toxic fescue (n = 25), or a rotation between toxic and non-toxic fescue (n = 25) for 156 days. Phenotypes impacted by breed (genetics) included hair coat score (p < 0.0001), hair reduction/shedding rate (p < 0.05), rectal temperature (RT) (p < 0.0001), vaginal temperature (p < 0.05), serum phosphorus concentration (p < 0.02) and respiration rate (RR) (p < 0.003). Cows on toxic fescue experienced reduced hair shedding efficacy (p < 0.0001), higher vaginal temperatures (p < 0.0001), increased systolic blood pressure (p < 0.04), increased RR (p < 0.0001) and reduced average daily gain (p < 0.0001), compared to cows grazing non-toxic fescue. Calves born from cows with higher RT during the last third of gestation had higher RT at weaning (p < 0.02), indicating potential physiological effects of in utero heat stress. The study indicates that beef cows exhibit variable responses to toxic fescue within and across breeds which may impact future calf phenotypes.