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The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells

A(3) adenosine receptor (A(3)AR) agonists have emerged as potent relievers of neuropathic pain by a T cell-mediated production of IL-10. The H(4) histamine receptor (H(4)R), also implicated in pain modulation, is expressed on T cells playing a preeminent role in its activation and release of IL-10....

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Detalles Bibliográficos
Autores principales: Micheli, Laura, Durante, Mariaconcetta, Lucarini, Elena, Sgambellone, Silvia, Lucarini, Laura, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Masini, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533073/
https://www.ncbi.nlm.nih.gov/pubmed/34680083
http://dx.doi.org/10.3390/biom11101447