Epigallocatechin-3-Gallate Suppresses BMP-6-Mediated SMAD1/5/8 Transactivation of Hepcidin Gene by Inducing SMILE in Hepatocytes

Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status. Small heterodimer partner-interacting leucine zipper protein (SMILE), a polyphenol-inducible transcriptio...

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Detalles Bibliográficos
Autores principales: Kim, Yu-Ji, Park, Woo-Ram, Choi, Byungyoon, Choi, Hueng-Sik, Kim, Don-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533173/
https://www.ncbi.nlm.nih.gov/pubmed/34679725
http://dx.doi.org/10.3390/antiox10101590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533173/
https://www.ncbi.nlm.nih.gov/pubmed/34679725
http://dx.doi.org/10.3390/antiox10101590

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