Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their physiological ubiquity and their prevalence in various diseases, including cancer. NUPR1 is an IDP that localizes throughout the whole cell, and is involved in the development and progression of sever...

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Detalles Bibliográficos
Autores principales: Rizzuti, Bruno, Lan, Wenjun, Santofimia-Castaño, Patricia, Zhou, Zhengwei, Velázquez-Campoy, Adrián, Abián, Olga, Peng, Ling, Neira, José L., Xia, Yi, Iovanna, Juan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533202/
https://www.ncbi.nlm.nih.gov/pubmed/34680086
http://dx.doi.org/10.3390/biom11101453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533202/
https://www.ncbi.nlm.nih.gov/pubmed/34680086
http://dx.doi.org/10.3390/biom11101453

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