Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors

A series of dietary flavonoid acacetin 7-O-methyl ether derivatives were computationally designed aiming to improve the selectivity and potency profiles against monoamine oxidase (MAO) B. The designed compounds were evaluated for their potential to inhibit human MAO-A and -B. Compounds 1c, 2c, 3c, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gogineni, Vedanjali, Nael, Manal A., Chaurasiya, Narayan D., Elokely, Khaled M., McCurdy, Christopher R., Rimoldi, John M., Cutler, Stephen J., Tekwani, Babu L., León, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533211/
https://www.ncbi.nlm.nih.gov/pubmed/34680421
http://dx.doi.org/10.3390/biomedicines9101304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533211/
https://www.ncbi.nlm.nih.gov/pubmed/34680421
http://dx.doi.org/10.3390/biomedicines9101304

Ejemplares similares