Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a promising therapeutical approach for Parkinson’s disease (PD). Herein, 24 melatonin analogues (3a–x) were synthesized as no...

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Detalles Bibliográficos
Autores principales: Elkamhawy, Ahmed, Woo, Jiyu, Gouda, Noha A., Kim, Jushin, Nada, Hossam, Roh, Eun Joo, Park, Ki Duk, Cho, Jungsook, Lee, Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533333/
https://www.ncbi.nlm.nih.gov/pubmed/34679739
http://dx.doi.org/10.3390/antiox10101604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533333/
https://www.ncbi.nlm.nih.gov/pubmed/34679739
http://dx.doi.org/10.3390/antiox10101604

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