Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells

Chronic hyperglycemia and hyperlipidemia hamper beta cell function, leading to glucolipotoxicity. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes, such as methylglyoxal (MG) and 4-hydroxynonenal (4-HNE), derived from glucose and lipids, respectively. We aimed to investig...

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Detalles Bibliográficos
Autores principales: Chen, Shiau-Mei, Hee, Siow-Wey, Chou, Shih-Yun, Liu, Meng-Wei, Chen, Che-Hong, Mochly-Rosen, Daria, Chang, Tien-Jyun, Chuang, Lee-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533366/
https://www.ncbi.nlm.nih.gov/pubmed/34680107
http://dx.doi.org/10.3390/biom11101474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533366/
https://www.ncbi.nlm.nih.gov/pubmed/34680107
http://dx.doi.org/10.3390/biom11101474

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