Cargando…

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells

Chronic hyperglycemia and hyperlipidemia hamper beta cell function, leading to glucolipotoxicity. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes, such as methylglyoxal (MG) and 4-hydroxynonenal (4-HNE), derived from glucose and lipids, respectively. We aimed to investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Shiau-Mei, Hee, Siow-Wey, Chou, Shih-Yun, Liu, Meng-Wei, Chen, Che-Hong, Mochly-Rosen, Daria, Chang, Tien-Jyun, Chuang, Lee-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533366/ https://www.ncbi.nlm.nih.gov/pubmed/34680107 http://dx.doi.org/10.3390/biom11101474

Ejemplares similares

Mitochondrial aldehyde dehydrogenase and cardiac diseases
por: Chen, Che-Hong, et al.
Publicado: (2010)

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
por: Nene, Aishwarya, et al.
Publicado: (2017)

Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment
por: Kim, Jeewon, et al.
Publicado: (2017)

Development of Selective Inhibitors for Aldehyde Dehydrogenases Based on Substituted Indole-2,3-diones
por: Kimble-Hill, Ann C., et al.
Publicado: (2014)

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
por: Joshi, Amit U., et al.
Publicado: (2019)

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism
por: Chiu, Ching-Chi, et al.
Publicado: (2014)

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese
por: Nakano, Yukiko, et al.
Publicado: (2016)

Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor
por: Kim, Jeewon, et al.
Publicado: (2017)

Glucolipotoxicity in Pancreatic β-Cells
por: Kim, Ji-Won, et al.
Publicado: (2011)

Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes
por: Saiki, Julie P., et al.
Publicado: (2018)

Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death
por: Chen, Yi-Chun, et al.
Publicado: (2023)

Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6
por: An, Xingxing, et al.
Publicado: (2016)

The Adaptor Protein NumbL Is Involved in the Control of Glucolipotoxicity-Induced Pancreatic Beta Cell Apoptosis
por: Basavarajappa, Halesha D., et al.
Publicado: (2023)

Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes
por: Cerf, Marlon E.
Publicado: (2020)

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis
por: Prause, Michala, et al.
Publicado: (2014)

Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate
por: Perrier, Johan, et al.
Publicado: (2023)

A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice
por: Lee, An-Sheng, et al.
Publicado: (2023)

Cardiac Glucolipotoxicity and Cardiovascular Outcomes
por: Cerf, Marlon E.
Publicado: (2018)

Glucolipotoxicity and GLP-1 secretion
por: Hong, Jung-Hee, et al.
Publicado: (2021)

Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice
por: Anastasiou, Vivian, et al.
Publicado: (2015)

PKR inhibitors suppress endoplasmic reticulum stress and subdue glucolipotoxicity-mediated impairment of insulin secretion in pancreatic beta cells
por: YALÇIN, Abdullah, et al.
Publicado: (2020)

Alcohol dehydrogenase and aldehyde dehydrogenase in malignant neoplasms
por: Orywal, Karolina, et al.
Publicado: (2016)

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?
por: Doliba, Nicolai M., et al.
Publicado: (2015)

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
por: Hwang, Sunhee, et al.
Publicado: (2018)

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options
por: McCarty, Mark F., et al.
Publicado: (2021)

Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population
por: Wu, Yah-Yuan, et al.
Publicado: (2021)

FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity
por: Pajaziti, Betina, et al.
Publicado: (2022)

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease
por: Wey, Margaret Chia-Ying, et al.
Publicado: (2012)

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
por: Viswanathan, Vignesh, et al.
Publicado: (2022)

Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease
por: Seike, Takuya, et al.
Publicado: (2023)

Amelioration of Glucolipotoxicity-Induced Endoplasmic Reticulum Stress by a “Chemical Chaperone” in Human THP-1 Monocytes
por: Lenin, Raji, et al.
Publicado: (2012)

SAXS fingerprints of aldehyde dehydrogenase oligomers
por: Tanner, John J.
Publicado: (2015)

Aldehyde Dehydrogenase, Liver Disease and Cancer
por: Wang, Wenjun, et al.
Publicado: (2020)

Aldehyde Dehydrogenase 1 in Gastric Cancer
por: Wang, Ling, et al.
Publicado: (2022)

Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists
por: Kusuma, Gina D., et al.
Publicado: (2017)

Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intramolecular charge transfer
por: Maity, Santanu, et al.
Publicado: (2017)

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice
por: Li, Meng, et al.
Publicado: (2018)

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE
por: Hsu, Lung-An, et al.
Publicado: (2020)

ALDH2 variance in disease and populations
por: Chen, Che-Hong, et al.
Publicado: (2022)

Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson’s disease
por: Yu, Rwei-Ling, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1qjqnbqiirvum6hg64l43a5g3t