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The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with c...

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Autores principales: Canyelles, Marina, García-Osuna, Álvaro, Junza, Alexandra, Yanes, Oscar, Puig, Núria, Ordóñez-Llanos, Jordi, Sionis, Alessandro, Sans-Roselló, Jordi, Alquézar-Arbé, Aitor, Santos, David, Rotllan, Noemi, Julve, Josep, Tondo, Mireia, Escolà-Gil, Joan Carles, Blanco-Vaca, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533386/
https://www.ncbi.nlm.nih.gov/pubmed/34680453
http://dx.doi.org/10.3390/biomedicines9101336
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author Canyelles, Marina
García-Osuna, Álvaro
Junza, Alexandra
Yanes, Oscar
Puig, Núria
Ordóñez-Llanos, Jordi
Sionis, Alessandro
Sans-Roselló, Jordi
Alquézar-Arbé, Aitor
Santos, David
Rotllan, Noemi
Julve, Josep
Tondo, Mireia
Escolà-Gil, Joan Carles
Blanco-Vaca, Francisco
author_facet Canyelles, Marina
García-Osuna, Álvaro
Junza, Alexandra
Yanes, Oscar
Puig, Núria
Ordóñez-Llanos, Jordi
Sionis, Alessandro
Sans-Roselló, Jordi
Alquézar-Arbé, Aitor
Santos, David
Rotllan, Noemi
Julve, Josep
Tondo, Mireia
Escolà-Gil, Joan Carles
Blanco-Vaca, Francisco
author_sort Canyelles, Marina
collection PubMed
description Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients.
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spelling pubmed-85333862021-10-23 The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction Canyelles, Marina García-Osuna, Álvaro Junza, Alexandra Yanes, Oscar Puig, Núria Ordóñez-Llanos, Jordi Sionis, Alessandro Sans-Roselló, Jordi Alquézar-Arbé, Aitor Santos, David Rotllan, Noemi Julve, Josep Tondo, Mireia Escolà-Gil, Joan Carles Blanco-Vaca, Francisco Biomedicines Article Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients. MDPI 2021-09-27 /pmc/articles/PMC8533386/ /pubmed/34680453 http://dx.doi.org/10.3390/biomedicines9101336 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Canyelles, Marina
García-Osuna, Álvaro
Junza, Alexandra
Yanes, Oscar
Puig, Núria
Ordóñez-Llanos, Jordi
Sionis, Alessandro
Sans-Roselló, Jordi
Alquézar-Arbé, Aitor
Santos, David
Rotllan, Noemi
Julve, Josep
Tondo, Mireia
Escolà-Gil, Joan Carles
Blanco-Vaca, Francisco
The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title_full The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title_fullStr The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title_full_unstemmed The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title_short The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction
title_sort capacity of apob-depleted plasma in inducing atp-binding cassette a1/g1-mediated macrophage cholesterol efflux—but not gut microbial-derived metabolites—is independently associated with mortality in patients with st-segment elevation myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533386/
https://www.ncbi.nlm.nih.gov/pubmed/34680453
http://dx.doi.org/10.3390/biomedicines9101336
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