Effect of Pirfenidone on TGF-β1-Induced Myofibroblast Differentiation and Extracellular Matrix Homeostasis of Human Orbital Fibroblasts in Graves’ Ophthalmopathy

Pirfenidone is a pyridinone derivative that has been shown to inhibit fibrosis in animal models and in patients with idiopathic pulmonary fibrosis. Its effect on orbital fibroblasts remains poorly understood. We investigated the in vitro effect of pirfenidone in transforming growth factor-β1 (TGF-β1...

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Detalles Bibliográficos
Autores principales: Wu, Shi-Bei, Hou, Tzu-Yu, Kau, Hui-Chuan, Tsai, Chieh-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533421/
https://www.ncbi.nlm.nih.gov/pubmed/34680057
http://dx.doi.org/10.3390/biom11101424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533421/
https://www.ncbi.nlm.nih.gov/pubmed/34680057
http://dx.doi.org/10.3390/biom11101424

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