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DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein

Glycation of α-synuclein (αSyn), as occurs with aging, has been linked to the progression of Parkinson’s disease (PD) through the promotion of advanced glycation end-products and the formation of toxic oligomers that cannot be properly cleared from neurons. DJ-1, an antioxidative protein that plays...

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Detalles Bibliográficos
Autores principales: Atieh, Tamr B., Roth, Jonathan, Yang, Xue, Hoop, Cody L., Baum, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533443/
https://www.ncbi.nlm.nih.gov/pubmed/34680099
http://dx.doi.org/10.3390/biom11101466