Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides

To rationalize the antiviral actions of plant alkaloids, the ability of 20 compounds to inhibit calcium-mediated fusion of lipid vesicles composed of phosphatidylglycerol and cholesterol was investigated using the calcein release assay and dynamic light scattering. Piperine, tabersonine, hordenine,...

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Detalles Bibliográficos
Autores principales: Shekunov, Egor V., Efimova, Svetlana S., Yudintceva, Natalia M., Muryleva, Anna A., Zarubaev, Vladimir V., Slita, Alexander V., Ostroumova, Olga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533497/
https://www.ncbi.nlm.nih.gov/pubmed/34680551
http://dx.doi.org/10.3390/biomedicines9101434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533497/
https://www.ncbi.nlm.nih.gov/pubmed/34680551
http://dx.doi.org/10.3390/biomedicines9101434

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