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Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production
Previously, a designed ankyrin repeat protein, Ank(GAG)1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process. Consequently, improved Ank(GAG)1D4 binding affinity was introduced by substituting tyrosine...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533564/ https://www.ncbi.nlm.nih.gov/pubmed/34680070 http://dx.doi.org/10.3390/biom11101437 |