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Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Previously, a designed ankyrin repeat protein, Ank(GAG)1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process. Consequently, improved Ank(GAG)1D4 binding affinity was introduced by substituting tyrosine...

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Detalles Bibliográficos
Autores principales:	Sornsuwan, Kanokporn, Thongkhum, Weeraya, Pamonsupornwichit, Thanathat, Carraway, Tanawan Samleerat, Soponpong, Suthinee, Sakkhachornphop, Supachai, Tayapiwatana, Chatchai, Yasamut, Umpa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533564/ https://www.ncbi.nlm.nih.gov/pubmed/34680070 http://dx.doi.org/10.3390/biom11101437

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