Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells

Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs lysosomes to enhance HIV-induced hepatotoxicity. We ex...

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Detalles Bibliográficos
Autores principales: New-Aaron, Moses, Thomes, Paul G., Ganesan, Murali, Dagur, Raghubendra Singh, Donohue, Terrence M., Kusum, Kharbanda K., Poluektova, Larisa Y., Osna, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533635/
https://www.ncbi.nlm.nih.gov/pubmed/34680130
http://dx.doi.org/10.3390/biom11101497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533635/
https://www.ncbi.nlm.nih.gov/pubmed/34680130
http://dx.doi.org/10.3390/biom11101497

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