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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS–CoV and MERS–CoV MDs in the free and the ADPr-bound state

SARS-CoV and MERS-CoV Macro Domains (MDs) exhibit topological and conformational features that resemble the nsP3b macro (or “X”) domain of SARS-CoV-2. Indeed, all the three domains (SARS-CoV-2, SARS-CoV and MERS-CoV MDs) fold in a three-layer α/β/α sandwich structure, as reported by crystallographic...

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Detalles Bibliográficos
Autores principales: Tsika, Aikaterini C., Fourkiotis, Nikolaos K., Charalampous, Periklis, Gallo, Angelo, Spyroulias, Georgios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533669/
https://www.ncbi.nlm.nih.gov/pubmed/34686999
http://dx.doi.org/10.1007/s12104-021-10052-5