High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders

Aseptic surgical trauma provokes the release of HMGB1, which engages the innate immune response after binding to pattern-recognition receptors on circulating bone marrow-derived monocytes (BM-DM). The initial systemic inflammation, together with HMGB1, disrupts the blood–brain barrier allowing penet...

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Detalles Bibliográficos
Autores principales: Saxena, Sarah, Kruys, Véronique, De Jongh, Raf, Vamecq, Joseph, Maze, Mervyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533835/
https://www.ncbi.nlm.nih.gov/pubmed/34685561
http://dx.doi.org/10.3390/cells10102582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533835/
https://www.ncbi.nlm.nih.gov/pubmed/34685561
http://dx.doi.org/10.3390/cells10102582

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