Irradiation Suppresses IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8(+) T Cells Cytotoxicity

Tumor cells express immune checkpoints to exhaust CD8(+) T cells. Irradiation damages tumor cells and augments tumor immunotherapy in clinical applications. However, the radiotherapy-mediated molecular mechanism affecting CD8(+) T cell activity remains elusive. We aimed to uncover the mechanism of r...

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Detalles Bibliográficos
Autores principales: Wang, Chun-I., Chang, Yi-Fang, Sie, Zong-Lin, Ho, Ai-Sheng, Chang, Jung-Shan, Peng, Cheng-Liang, Cheng, Chun-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533912/
https://www.ncbi.nlm.nih.gov/pubmed/34685495
http://dx.doi.org/10.3390/cells10102515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533912/
https://www.ncbi.nlm.nih.gov/pubmed/34685495
http://dx.doi.org/10.3390/cells10102515

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