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Pirfenidone Reduces Epithelial–Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs)

SIMPLE SUMMARY: Cancer-associated fibroblasts (CAFs) stimulate phenotypic transformation and acquisition of stemness in carcinoma cells. Targeting CAF-derived cytokines may suppress initiation of these events. This study aimed to show the inhibitory effects of pirfenidone on phenotypic transformatio...

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Detalles Bibliográficos
Autores principales:	Es, Hamidreza Aboulkheyr, Cox, Thomas R, Sarafraz-Yazdi, Ehsan, Thiery, Jean Paul, Warkiani, Majid Ebrahimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533995/ https://www.ncbi.nlm.nih.gov/pubmed/34680267 http://dx.doi.org/10.3390/cancers13205118

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