Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells

SIMPLE SUMMARY: Metabolic rewiring fuels cancer proliferation by enhanced glycolysis and the increased NADH/NAD(+) ratio. In this study, we highlight the critical role of NADH in the epigenetic landscape mediated by CtBP2 (C-terminal binding protein 2) activation, linking metabolism to epigenetic tr...

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Detalles Bibliográficos
Autores principales: Bonanomi, Marcella, Salmistraro, Noemi, Fiscon, Giulia, Conte, Federica, Paci, Paola, Bravatà, Valentina, Forte, Giusi Irma, Volpari, Tatiana, Scorza, Manuela, Mastroianni, Fabrizia, D’Errico, Stefano, Avolio, Elenio, Piccialli, Gennaro, Colangelo, Anna Maria, Vanoni, Marco, Gaglio, Daniela, Alberghina, Lilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534001/
https://www.ncbi.nlm.nih.gov/pubmed/34680207
http://dx.doi.org/10.3390/cancers13205058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534001/
https://www.ncbi.nlm.nih.gov/pubmed/34680207
http://dx.doi.org/10.3390/cancers13205058

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