Enhanced IFNα Signaling Promotes Ligand-Independent Activation of ERα to Promote Aromatase Inhibitor Resistance in Breast Cancer

SIMPLE SUMMARY: Interferon alpha (IFNα) signaling is highly upregulated in ER+ breast cancers that become resistant to estrogen deprivation therapy. This study uncovers how enhanced (IFNα)/JAK-STAT signaling directly influences estrogen receptor (ERα) activation in the absence of estrogen. We found...

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Detalles Bibliográficos
Autores principales: Escher, Taylor E., Dandawate, Prasad, Sayed, Afreen, Hagan, Christy R., Anant, Shrikant, Lewis-Wambi, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534010/
https://www.ncbi.nlm.nih.gov/pubmed/34680281
http://dx.doi.org/10.3390/cancers13205130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534010/
https://www.ncbi.nlm.nih.gov/pubmed/34680281
http://dx.doi.org/10.3390/cancers13205130

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