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Enhanced IFNα Signaling Promotes Ligand-Independent Activation of ERα to Promote Aromatase Inhibitor Resistance in Breast Cancer

SIMPLE SUMMARY: Interferon alpha (IFNα) signaling is highly upregulated in ER+ breast cancers that become resistant to estrogen deprivation therapy. This study uncovers how enhanced (IFNα)/JAK-STAT signaling directly influences estrogen receptor (ERα) activation in the absence of estrogen. We found...

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Detalles Bibliográficos
Autores principales:	Escher, Taylor E., Dandawate, Prasad, Sayed, Afreen, Hagan, Christy R., Anant, Shrikant, Lewis-Wambi, Joan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534010/ https://www.ncbi.nlm.nih.gov/pubmed/34680281 http://dx.doi.org/10.3390/cancers13205130

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