Phospho-Ser(784)-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor

SIMPLE SUMMARY: Defining the mechanisms underlying the heterogeneous cancer cell response to DNA damage is important for our ability to tailor individualized strategies to improve chemotherapy efficacy. In this study, we focus on a central DNA repair regulator named VCP whose loss-of-function has be...

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Detalles Bibliográficos
Autores principales: Wang, Faliang, Vij, Kiran, Li, Lin, Dodhiawala, Paarth, Lim, Kian-Huat, Shao, Jieya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534018/
https://www.ncbi.nlm.nih.gov/pubmed/34680224
http://dx.doi.org/10.3390/cancers13205076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534018/
https://www.ncbi.nlm.nih.gov/pubmed/34680224
http://dx.doi.org/10.3390/cancers13205076

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