Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

SIMPLE SUMMARY: The two human p70 ribosomal S6 kinases, S6K1 and S6K2, have been associated with a variety of cellular processes and human pathologies, especially cancer. Thus far, only S6K1 was thoroughly studied and selectively addressed by small molecule inhibitors. Despite growing evidence sugge...

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Detalles Bibliográficos
Autores principales: Gerstenecker, Stefan, Haarer, Lisa, Schröder, Martin, Kudolo, Mark, Schwalm, Martin P., Wydra, Valentin, Serafim, Ricardo A. M., Chaikuad, Apirat, Knapp, Stefan, Laufer, Stefan, Gehringer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534050/
https://www.ncbi.nlm.nih.gov/pubmed/34680283
http://dx.doi.org/10.3390/cancers13205133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534050/
https://www.ncbi.nlm.nih.gov/pubmed/34680283
http://dx.doi.org/10.3390/cancers13205133

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