Cargando…

The Prevalence of Pathogenic or Likely Pathogenic Germline Variants in a Nationwide Cohort of Young Colorectal Cancer Patients Using a Panel of 18 Genes Associated with Colorectal Cancer

SIMPLE SUMMARY: This study reveals that pathogenic or likely pathogenic germline variants are detected in one fourth of all young patients with colorectal cancer in a nationwide cohort. Immunohistochemistry staining for mismatch repair deficiency is an easy way to detect Lynch syndrome in the young...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frostberg, Erik, Petersen, Annabeth Høgh, Bojesen, Anders, Rahr, Hans Bjarke, Lindebjerg, Jan, Rønlund, Karina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534092/ https://www.ncbi.nlm.nih.gov/pubmed/34680242 http://dx.doi.org/10.3390/cancers13205094

Ejemplares similares

Post-mortem testing; germline BRCA1/2 variant detection using archival FFPE non-tumor tissue. A new paradigm in genetic counseling
por: Petersen, Annabeth Høgh, et al.
Publicado: (2016)

Impact of an in-consult patient decision aid on treatment choices and outcomes of management for patients with an endoscopically resected malignant colorectal polyp: a study protocol for a non-randomised clinical phase II study
por: Würtz, Helene Juul, et al.
Publicado: (2023)

Uneven Between-Hospital Distribution of Patient-Related Risk Factors for Adverse Outcomes of Colorectal Cancer Treatment: A Population-Based Register Study
por: Rattenborg, Søren, et al.
Publicado: (2023)

Sociodemographic characteristics of nonparticipants in the Danish colorectal cancer screening program: a nationwide cross-sectional study
por: Larsen, Mette Bach, et al.
Publicado: (2017)

The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study
por: Pedersen, Malene Roland V., et al.
Publicado: (2021)

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients
por: Djursby, Malene, et al.
Publicado: (2020)

Endorectal Ultrasound Shear-Wave Elastography of Complex Rectal Adenoma and Early Rectal Cancer
por: Loft, Martina Kastrup, et al.
Publicado: (2022)

The repertoire of germline variants in patients with early‐onset rectal cancer
por: Beltrami, Caroline Moraes, et al.
Publicado: (2022)

Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer
por: Nguyen-Dumont, Tú, et al.
Publicado: (2021)

Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer
por: Toh, Ming Ren, et al.
Publicado: (2018)

Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
por: Chang, Pi-Yueh, et al.
Publicado: (2020)

Case Report Series: Aggressive HR Deficient Colorectal Cancers Related to BRCA1 Pathogenic Germline Variants
por: Freire, Maria Valeria, et al.
Publicado: (2022)

Detection of germline variants with pathogenic potential in 48 patients with familial colorectal cancer by using whole exome sequencing
por: Singh, Ashish Kumar, et al.
Publicado: (2023)

Bacterial, Viral and Parasitic Pathogens and Colorectal Cancer
por: Kato, Ikuko
Publicado: (2023)

Half of germline pathogenic and likely pathogenic variants found on panel tests do not fulfil NHS testing criteria
por: Andoni, Tala, et al.
Publicado: (2022)

Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients
por: Rashid, Muhammad Usman, et al.
Publicado: (2019)

Canonical and uncanonical pathogenic germline variants in colorectal cancer patients by next-generation sequencing in a European referral center
por: Poliani, L., et al.
Publicado: (2022)

The prevalence of germline pathogenic variants in Estonian colorectal cancer patients: results from routine clinical setting 2016–2021
por: Roht, Laura, et al.
Publicado: (2022)

Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence
por: Hassanin, Emadeldin, et al.
Publicado: (2023)

Local staging of sigmoid colon cancer using MRI
por: Dam, Claus, et al.
Publicado: (2017)

Prevalence of Germline Pathogenic and Likely Pathogenic Variants in Patients With Second Breast Cancers
por: Yao K, Katharine A, et al.
Publicado: (2020)

POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East
por: Siraj, Abdul K., et al.
Publicado: (2020)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations
por: Thirlwell, C, et al.
Publicado: (2007)

Rate of Pathogenic Germline Variants in Patients With Lung Cancer
por: Sorscher, Steven, et al.
Publicado: (2023)

AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer
por: Leclerc, Julie, et al.
Publicado: (2022)

Completion of Genetic Testing and Incidence of Pathogenic Germline Mutation among Patients with Early-Onset Colorectal Cancer: A Single Institution Analysis
por: Storandt, Michael H., et al.
Publicado: (2023)

The predictive value of microRNA-126 in relation to first line treatment with capecitabine and oxaliplatin in patients with metastatic colorectal cancer
por: Hansen, Torben Frøstrup, et al.
Publicado: (2012)

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
por: Zhao, Hui, et al.
Publicado: (2022)

Early identification of treatment benefit by methylated circulating tumor DNA in metastatic colorectal cancer
por: Thomsen, Caroline B., et al.
Publicado: (2020)

Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants
por: Hinoi, Takao
Publicado: (2021)

The prevalence of germline DICER1 pathogenic variation in cancer populations
por: Kim, Jung, et al.
Publicado: (2019)

Germline pathogenic variants in unselected Korean men with prostate cancer
por: So, Min-Kyung, et al.
Publicado: (2022)

EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer
por: Spindler, Karen-Lise G, et al.
Publicado: (2011)

Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients
por: von Stedingk, Kristoffer, et al.
Publicado: (2021)

Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer
por: Lee, Ning-Yuan, et al.
Publicado: (2023)

The Prognostic Value of Haplotypes in the Vascular Endothelial Growth Factor A Gene in Colorectal Cancer
por: Hansen, Torben F., et al.
Publicado: (2010)

Germline pathogenic variants in 786 neuroblastoma patients
por: Kim, Jung, et al.
Publicado: (2023)

Heterogenous mismatch-repair status in colorectal cancer
por: Joost, Patrick, et al.
Publicado: (2014)

Germline EPHB2 Receptor Variants in Familial Colorectal Cancer
por: Zogopoulos, George, et al.
Publicado: (2008)

Mitogenome germline mutations and colorectal cancer risk in Polish population
por: Skonieczna, Katarzyna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mkjca1hb4knfrolq8qcqmthmko