Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of HLA Class I Alterations in Cancer

SIMPLE SUMMARY: Loss of antigen presentation due to the altered expression of tumor HLA class I (HLA-I) molecules is a common mechanism of cancer immune escape. Loss of HLA-I haplotype, locus or a single allele due to genetic and chromosomal aberrations, may result in reduced antigen presentation an...

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Detalles Bibliográficos
Autores principales: Garrido, Maria Antonia, Perea, Francisco, Vilchez, Jose Ramon, Rodríguez, Teresa, Anderson, Per, Garrido, Federico, Ruiz-Cabello, Francisco, Aptsiauri, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534100/
https://www.ncbi.nlm.nih.gov/pubmed/34680201
http://dx.doi.org/10.3390/cancers13205046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534100/
https://www.ncbi.nlm.nih.gov/pubmed/34680201
http://dx.doi.org/10.3390/cancers13205046

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