Cargando…

Lamin B1 Accumulation’s Effects on Autosomal Dominant Leukodystrophy (ADLD): Induction of Reactivity in the Astrocytes

Autosomal dominant leukodystrophy (ADLD) is an extremely rare and fatal neurodegenerative disease due to the overexpression of the nuclear lamina component Lamin B1. Many aspects of the pathology still remain unrevealed. This work highlights the effect of Lamin B1 accumulation on different cellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ratti, Stefano, Rusciano, Isabella, Mongiorgi, Sara, Neri, Irene, Cappellini, Alessandra, Cortelli, Pietro, Suh, Pann-Ghill, McCubrey, James A., Manzoli, Lucia, Cocco, Lucio, Ramazzotti, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534128/ https://www.ncbi.nlm.nih.gov/pubmed/34685544 http://dx.doi.org/10.3390/cells10102566

Ejemplares similares

Cell signaling pathways in autosomal-dominant leukodystrophy (ADLD): the intriguing role of the astrocytes
por: Ratti, Stefano, et al.
Publicado: (2020)

Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models
por: Neri, Irene, et al.
Publicado: (2023)

The wide and growing range of lamin B-related diseases: from laminopathies to cancer
por: Evangelisti, Camilla, et al.
Publicado: (2022)

A novel DAG-dependent mechanism links PKCa and Cyclin B1 regulating cell cycle progression
por: Poli, Alessandro, et al.
Publicado: (2014)

Impact of phospholipase C β1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness
por: Ratti, Stefano, et al.
Publicado: (2022)

Lamin B1 as a key modulator of the developing and aging brain
por: Koufi, Foteini-Dionysia, et al.
Publicado: (2023)

Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases
por: Fazio, Antonietta, et al.
Publicado: (2020)

A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
por: Giorgio, Elisa, et al.
Publicado: (2015)

Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes
por: Xian, Jie, et al.
Publicado: (2020)

Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts
por: Ferrera, Denise, et al.
Publicado: (2014)

A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes
por: Mongiorgi, Sara, et al.
Publicado: (2023)

Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside
por: Marvi, Maria Vittoria, et al.
Publicado: (2023)

Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes
por: Owusu Obeng, Eric, et al.
Publicado: (2020)

Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes
por: Follo, Matilde Y., et al.
Publicado: (2019)

Roles of PI3K/AKT/mTOR Axis in Arteriovenous Fistula
por: Ratti, Stefano, et al.
Publicado: (2022)

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation
por: Ramazzotti, Giulia, et al.
Publicado: (2016)

Genomic deletions upstream of lamin B1 lead to atypical autosomal dominant leukodystrophy
por: Nmezi, Bruce, et al.
Publicado: (2019)

Messenger RNA processing is altered in autosomal dominant leukodystrophy(†)
por: Bartoletti-Stella, Anna, et al.
Publicado: (2015)

Messenger RNA processing is altered in autosomal dominant leukodystrophy
por: Bartoletti-Stella, Anna, et al.
Publicado: (2017)

Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments
por: Ramazzotti, Giulia, et al.
Publicado: (2019)

ADLD: A Novel Graphical Representation of Protein Sequences and Its Application
por: Wang, Lei, et al.
Publicado: (2014)

Clinical and Molecular Insights in Erythropoiesis Regulation of Signal Transduction Pathways in Myelodysplastic Syndromes and β-Thalassemia
por: Parisi, Sarah, et al.
Publicado: (2021)

Near-Peer Teaching in Human Anatomy from a Tutors’ Perspective: An Eighteen-Year-Old Experience at the University of Bologna
por: Orsini, Ester, et al.
Publicado: (2021)

PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells
por: Bavelloni, Alberto, et al.
Publicado: (2014)

Autosomal Dominant Leukodystrophy: A Disease of the Nuclear Lamina
por: Padiath, Quasar S.
Publicado: (2019)

Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner
por: Zawiślak, Alina, et al.
Publicado: (2017)

Emerging Roles of Phospholipase C Beta Isozymes as Potential Biomarkers in Cardiac Disorders
por: Fazio, Antonietta, et al.
Publicado: (2023)

LMNB1‐related autosomal‐dominant leukodystrophy: Clinical and radiological course
por: Finnsson, Johannes, et al.
Publicado: (2015)

Glucose metabolism in the brain in LMNB1‐related autosomal dominant leukodystrophy
por: Finnsson, Johannes, et al.
Publicado: (2018)

Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter
por: Leferink, Prisca S., et al.
Publicado: (2017)

Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
por: Steelman, Linda S., et al.
Publicado: (2017)

Duplication and deletion upstream of LMNB1 in autosomal dominant adult-onset leukodystrophy
por: Mezaki, Naomi, et al.
Publicado: (2018)

The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy
por: Herrero, Melisa, et al.
Publicado: (2021)

Analysis of LMNB1 Duplications in Autosomal Dominant Leukodystrophy Provides Insights into Duplication Mechanisms and Allele-Specific Expression
por: Giorgio, Elisa, et al.
Publicado: (2013)

APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells
por: McCubrey, James Andrew, et al.
Publicado: (2022)

LMNB1 Duplication-Mediated Autosomal Dominant Adult-Onset Leukodystrophy in an Indian Family
por: Bijarnia-Mahay, Sunita, et al.
Publicado: (2021)

O‐GlcNAcylation regulates lysophosphatidic acid‐induced cell migration by regulating ERM family proteins
por: Song, Minseok, et al.
Publicado: (2022)

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells
por: Evangelisti, Camilla, et al.
Publicado: (2020)

Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies
por: Lanciotti, Angela, et al.
Publicado: (2021)

Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression
por: McCubrey, James A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ou628l0d61b2jata6j3625o6ak