Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO(P23H) Rat Retinal Explants

Rhodopsin (RHO) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, RHO(P23H), results in its misfolding and retention in the endoplasmic reticulum (ER). Under homeostatic conditions, misfolded proteins are sele...

Descripción completa

Detalles Bibliográficos
Autores principales: Sen, Merve, Kutsyr, Oksana, Cao, Bowen, Bolz, Sylvia, Arango-Gonzalez, Blanca, Ueffing, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534135/
https://www.ncbi.nlm.nih.gov/pubmed/34680161
http://dx.doi.org/10.3390/biom11101528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534135/
https://www.ncbi.nlm.nih.gov/pubmed/34680161
http://dx.doi.org/10.3390/biom11101528

Ejemplares similares