Natural Product Isoliquiritigenin Activates GABA(B) Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals

Reduction in glutamate release is a key mechanism for neuroprotection and we investigated the effect of isoliquiritigenin (ISL), an active ingredient of Glycyrrhiza with neuroprotective activities, on glutamate release in rat cerebrocortical nerve terminals (synaptosomes). ISL produced a concentrati...

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Detalles Bibliográficos
Autores principales: Lin, Tzu-Yu, Lu, Cheng-Wei, Hsieh, Pei-Wen, Chiu, Kuan-Ming, Lee, Ming-Yi, Wang, Su-Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534184/
https://www.ncbi.nlm.nih.gov/pubmed/34680170
http://dx.doi.org/10.3390/biom11101537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534184/
https://www.ncbi.nlm.nih.gov/pubmed/34680170
http://dx.doi.org/10.3390/biom11101537

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