Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a dismal prognosis. Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of epigenetic modifiers of the histone deacetylase (HDAC) family aff...

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Detalles Bibliográficos
Autores principales: Nguyen, Alexandra, Dzulko, Melanie, Murr, Janine, Yen, Yun, Schneider, Günter, Krämer, Oliver H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534202/
https://www.ncbi.nlm.nih.gov/pubmed/34685500
http://dx.doi.org/10.3390/cells10102520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534202/
https://www.ncbi.nlm.nih.gov/pubmed/34685500
http://dx.doi.org/10.3390/cells10102520

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